Fractyl Health plans to reduce its workforce by about 45%

Fractyl Health announced on October 22, 2026, that it plans to reduce its workforce by about 45% as it directs resources toward its Revita program.

The Burlington, Massachusetts-based company expects the reduction to be substantially completed by November 2026. Its SEC filing says the plan was adopted October 21 and completion is expected in the fourth quarter. These are planned reductions, not a confirmed completed count.

Fractyl is also ending internal development of its Rejuva gene-therapy program while seeking alternatives for that program. The company is continuing operations. Neither the release nor the filing provides a precise number of affected employees.